Drugs against Mycobacterium tuberculosis 3-isopropylmalate dehydrogenase can be developed using homologous enzymes as surrogate targets.

Graczer, Eva; Bacso, Andras; Konya, Denes; Kazi, Adrian; Soos, Tibor; Molnar, Laura; Szimler, Tamas; Beinrohr, Laszlo; Szilagyi, Andras; Zavodszky, Peter; Vas, Maria

Graczer, Eva; Bacso, Andras; Konya, Denes; Kazi, Adrian; Soos, Tibor; Molnar, Laura; Szimler, Tamas; Beinrohr, Laszlo; Szilagyi, Andras; Zavodszky, Peter; Vas, Maria.

Affiliation

Vas M; Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, H- 1117 Budapest, Magyar tudósok korutja 2., Hungary; H-1519 Budapest, P. O. Box 286., Hungary. vas.maria@ttk.mta.hu.

Protein Pept Lett ; 21(12): 1295-307, 2014.

Article in En | MEDLINE | ID: mdl-24909230

Subject(s)

3-Isopropylmalate Dehydrogenase/metabolism; Antitubercular Agents/metabolism; Bacterial Proteins/metabolism; Mycobacterium tuberculosis/enzymology; 3-Isopropylmalate Dehydrogenase/chemistry; 3-Isopropylmalate Dehydrogenase/drug effects; 3-Isopropylmalate Dehydrogenase/genetics; Antitubercular Agents/pharmacology; Bacterial Proteins/chemistry; Bacterial Proteins/drug effects; Bacterial Proteins/genetics; Catalytic Domain; Drug Discovery; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mycobacterium tuberculosis/genetics; Protein Refolding

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Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / 3-Isopropylmalate Dehydrogenase / Mycobacterium tuberculosis / Antitubercular Agents Language: En Journal: Protein Pept Lett Journal subject: BIOQUIMICA Year: 2014 Type: Article

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