Nonhuman genetics. Strong male bias drives germline mutation in chimpanzees.
Science
; 344(6189): 1272-5, 2014 Jun 13.
Article
in En
| MEDLINE
| ID: mdl-24926018
ABSTRACT
Germline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10(-8) per base pair per generation, with every additional year of father's age contributing two mutations across the genome and males contributing three to four times as many mutations as females. To assess whether such patterns are shared with our closest living relatives, we sequenced the genomes of a nine-member pedigree of Western chimpanzees, Pan troglodytes verus. Our results indicate a mutation rate of 1.2 × 10(-8) per base pair per generation, but a male contribution seven to eight times that of females and a paternal age effect of three mutations per year of father's age. Thus, mutation rates and patterns differ between closely related species.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pan troglodytes
/
Models, Statistical
/
Germ-Line Mutation
/
Models, Genetic
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Science
Year:
2014
Type:
Article
Affiliation country:
United kingdom