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The R292K mutation that confers resistance to neuraminidase inhibitors leads to competitive fitness loss of A/Shanghai/1/2013 (H7N9) influenza virus in ferrets.
Yen, Hui-Ling; Zhou, Jie; Choy, Ka-Tim; Sia, Sin Fun; Teng, Ooiean; Ng, Iris H; Fang, Vicky J; Hu, Yunwen; Wang, Wei; Cowling, Benjamin J; Nicholls, John M; Guan, Yi; Peiris, Joseph Sriyal Malik.
Affiliation
  • Yen HL; School of Public Health.
  • Zhou J; School of Public Health.
  • Choy KT; School of Public Health.
  • Sia SF; School of Public Health.
  • Teng O; School of Public Health.
  • Ng IH; School of Public Health.
  • Fang VJ; School of Public Health.
  • Hu Y; Shanghai Public Health Clinical Center, China.
  • Wang W; Shanghai Public Health Clinical Center, China.
  • Cowling BJ; School of Public Health.
  • Nicholls JM; Department of Pathology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong SAR.
  • Guan Y; School of Public Health.
  • Peiris JS; School of Public Health.
J Infect Dis ; 210(12): 1900-8, 2014 Dec 15.
Article in En | MEDLINE | ID: mdl-24951824
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Orthomyxoviridae Infections / Mutation, Missense / Drug Resistance, Viral / Influenza A Virus, H7N9 Subtype / Neuraminidase Limits: Animals Language: En Journal: J Infect Dis Year: 2014 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / Orthomyxoviridae Infections / Mutation, Missense / Drug Resistance, Viral / Influenza A Virus, H7N9 Subtype / Neuraminidase Limits: Animals Language: En Journal: J Infect Dis Year: 2014 Type: Article