Concomitant exposure to ovalbumin and endotoxin augments airway inflammation but not airway hyperresponsiveness in a murine model of asthma.

Mac Sharry, John; Shalaby, Karim H; Marchica, Cinzia; Farahnak, Soroor; Chieh-Li, Tien; Lapthorne, Susan; Qureshi, Salman T; Shanahan, Fergus; Martin, James G

Mac Sharry, John; Shalaby, Karim H; Marchica, Cinzia; Farahnak, Soroor; Chieh-Li, Tien; Lapthorne, Susan; Qureshi, Salman T; Shanahan, Fergus; Martin, James G.

Affiliation

Mac Sharry J; Alimentary Pharmabiotic Centre, School of Medicine, University College Cork, National University of Ireland, Cork, Ireland.
Shalaby KH; Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Canada.
Marchica C; Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Canada.
Farahnak S; Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Canada.
Chieh-Li T; Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Canada.
Lapthorne S; Alimentary Pharmabiotic Centre, School of Medicine, University College Cork, National University of Ireland, Cork, Ireland.
Qureshi ST; Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Canada.
Shanahan F; Alimentary Pharmabiotic Centre, School of Medicine, University College Cork, National University of Ireland, Cork, Ireland.
Martin JG; Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Canada.

PLoS One ; 9(6): e98648, 2014.

Article in En | MEDLINE | ID: mdl-24968337

Subject(s)

Asthma/etiology; Lipopolysaccharides/toxicity; Ovalbumin/toxicity; Respiratory Hypersensitivity/etiology; Animals; Asthma/immunology; Bronchoalveolar Lavage Fluid/cytology; Cells, Cultured; Drug Synergism; Eosinophils/immunology; Humans; Inflammation/etiology; Inflammation/immunology; Interferon-gamma/genetics; Interferon-gamma/metabolism; Interleukins/genetics; Interleukins/metabolism; Lipopolysaccharides/immunology; Male; Mice; Mice, Inbred BALB C; Neutrophils/immunology; Ovalbumin/immunology; Respiratory Hypersensitivity/immunology; T-Lymphocytes, Regulatory/immunology; Th2 Cells/immunology; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Hypersensitivity / Asthma / Ovalbumin / Lipopolysaccharides Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Type: Article Affiliation country: Ireland

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