Ethanol:water mutually enhanced transdermal therapeutic system. I: Nitroglycerin solution properties and membrane transport.
J Pharm Sci
; 78(4): 314-8, 1989 Apr.
Article
in En
| MEDLINE
| ID: mdl-2498509
ABSTRACT
The solution properties of aqueous ethanol donor solutions were characterized for the particular case of an increased flux nitroglycerin transdermal system. Permeation through porous and nonporous polymer membranes was investigated and modelled. While the permeation of ethanol through the porous membranes is adequately described by theory, clogging of pores occurs in the presence of lactose. Permeation through ethylene vinyl acetate membranes reflects interactions of the solute and solvent with the polymer.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nitroglycerin
Language:
En
Journal:
J Pharm Sci
Year:
1989
Type:
Article