Ethanol: water mutually enhanced transdermal therapeutic system II: skin permeation of ethanol and nitroglycerin.
J Pharm Sci
; 78(5): 402-7, 1989 May.
Article
in En
| MEDLINE
| ID: mdl-2501473
ABSTRACT
An optimal concentration range of aqueous ethanol produces 5-10-fold increases in nitroglycerin flux across skin and ethanol skin permeation that are far greater than reported previously. For aqueous ethanol solutions saturated with nitroglycerin with an ethanol volume fraction less than or equal to 0.7, the flux of nitroglycerin across skin is linear with the ethanol flux and is traced to a linear solubility relationship and a constant diffusion coefficient.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Absorption
/
Nitroglycerin
/
Ethanol
Limits:
Humans
Language:
En
Journal:
J Pharm Sci
Year:
1989
Type:
Article