Anti-Inflammatory Agents/toxicity; Edema/drug therapy; Inflammation/drug therapy; Plant Extracts/toxicity; Verbenaceae; Administration, Oral; Alanine Transaminase/blood; Animals; Anti-Inflammatory Agents/isolation & purification; Aspartate Aminotransferases/blood; Carrageenan/administration & dosage; Chile; Female; Heart/drug effects; Hindlimb/injuries; Indomethacin/therapeutic use; Kidney/drug effects; Liquid-Liquid Extraction; Liver/drug effects; Lung/drug effects; Male; Medicine, Traditional; Myocardium; Ovary/drug effects; Plant Extracts/chemistry; Plant Leaves/chemistry; Rats, Sprague-Dawley; Testis/drug effects; Toxicity Tests, Acute/methods