Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels.

Lu, Silu; Xiang, Lusha; Clemmer, John S; Mittwede, Peter N; Hester, Robert L

Lu, Silu; Xiang, Lusha; Clemmer, John S; Mittwede, Peter N; Hester, Robert L.

Affiliation

Lu S; Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Microcirculation ; 21(8): 754-60, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25059284

Subject(s)

Capillary Permeability; Diabetes Mellitus, Experimental/metabolism; Lung/metabolism; Oxidative Stress; Potassium/metabolism; TRPM Cation Channels/metabolism; Acetophenones/pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Boron Compounds/pharmacology; Diabetes Mellitus, Experimental/pathology; Lung/pathology; Male; Rats; Rats, Zucker; TRPM Cation Channels/antagonists & inhibitors

Key words

TRPM2; hyperglycemia; lung permeability; superoxide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Potassium / Capillary Permeability / Oxidative Stress / Diabetes Mellitus, Experimental / TRPM Cation Channels / Lung Limits: Animals Language: En Journal: Microcirculation Journal subject: ANGIOLOGIA Year: 2014 Type: Article Affiliation country: United States

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