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Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.
Calabrese, Matthew F; Rajamohan, Francis; Harris, Melissa S; Caspers, Nicole L; Magyar, Rachelle; Withka, Jane M; Wang, Hong; Borzilleri, Kris A; Sahasrabudhe, Parag V; Hoth, Lise R; Geoghegan, Kieran F; Han, Seungil; Brown, Janice; Subashi, Timothy A; Reyes, Allan R; Frisbie, Richard K; Ward, Jessica; Miller, Russell A; Landro, James A; Londregan, Allyn T; Carpino, Philip A; Cabral, Shawn; Smith, Aaron C; Conn, Edward L; Cameron, Kimberly O; Qiu, Xiayang; Kurumbail, Ravi G.
Affiliation
  • Calabrese MF; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Rajamohan F; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Harris MS; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Caspers NL; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Magyar R; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Withka JM; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Wang H; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Borzilleri KA; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Sahasrabudhe PV; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Hoth LR; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Geoghegan KF; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Han S; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Brown J; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Subashi TA; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Reyes AR; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Frisbie RK; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Ward J; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Miller RA; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Landro JA; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Londregan AT; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Carpino PA; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Cabral S; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Smith AC; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Conn EL; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Cameron KO; Worldwide Research and Development, Pfizer Inc., 610 Main Street, Cambridge, MA 02139, USA.
  • Qiu X; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA.
  • Kurumbail RG; Worldwide Research and Development, Pfizer Inc., Eastern Point Road, Groton, CT 06340, USA. Electronic address: ravi.g.kurumbail@pfizer.com.
Structure ; 22(8): 1161-1172, 2014 Aug 05.
Article in En | MEDLINE | ID: mdl-25066137
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Molecular / Enzyme Activation / AMP-Activated Protein Kinases Limits: Humans Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2014 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Models, Molecular / Enzyme Activation / AMP-Activated Protein Kinases Limits: Humans Language: En Journal: Structure Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Year: 2014 Type: Article Affiliation country: United States