LL-37 peptide enhancement of signal transduction by Toll-like receptor 3 is regulated by pH: identification of a peptide antagonist of LL-37.

Singh, Divyendu; Vaughan, Robert; Kao, C Cheng

Singh, Divyendu; Vaughan, Robert; Kao, C Cheng.

Affiliation

Singh D; From the Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405.
Vaughan R; From the Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405.
Kao CC; From the Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405 ckao@indiana.edu.

J Biol Chem ; 289(40): 27614-24, 2014 Oct 03.

Article in En | MEDLINE | ID: mdl-25092290

Subject(s)

Antimicrobial Cationic Peptides/metabolism; Peptides/chemistry; Signal Transduction; Toll-Like Receptor 3/metabolism; Amino Acid Sequence; Antimicrobial Cationic Peptides/antagonists & inhibitors; Antimicrobial Cationic Peptides/chemistry; Antimicrobial Cationic Peptides/genetics; Binding Sites; Endosomes/metabolism; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Peptides/metabolism; RNA, Double-Stranded/metabolism; Toll-Like Receptor 3/chemistry; Toll-Like Receptor 3/genetics; Up-Regulation; Cathelicidins

Key words

Endosome; Innate Immunity; RNA-binding Protein; Toll-like Receptor (TLR); pH; pH Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Signal Transduction / Antimicrobial Cationic Peptides / Toll-Like Receptor 3 Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2014 Type: Article

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