Effect of ursodeoxycholic acid treatment on the altered progesterone and bile acid homeostasis in the mother-placenta-foetus trio during cholestasis of pregnancy.

Estiú, Maria C; Monte, Maria J; Rivas, Laura; Moirón, Maria; Gomez-Rodriguez, Laura; Rodriguez-Bravo, Tomas; Marin, Jose J G; Macias, Rocio I R

Estiú, Maria C; Monte, Maria J; Rivas, Laura; Moirón, Maria; Gomez-Rodriguez, Laura; Rodriguez-Bravo, Tomas; Marin, Jose J G; Macias, Rocio I R.

Affiliation

Estiú MC; Ramón Sardá Mother' and Children's Hospital, Buenos Aires, Argentina.

Br J Clin Pharmacol ; 79(2): 316-29, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25099365

Subject(s)

Bile Acids and Salts/metabolism; Cholestasis, Intrahepatic/drug therapy; Pregnancy Complications/drug therapy; Progesterone/metabolism; Ursodeoxycholic Acid/pharmacology; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters/genetics; Adolescent; Adult; Cholestasis, Intrahepatic/physiopathology; Chromatography, High Pressure Liquid/methods; Cohort Studies; Female; Fetus/metabolism; Humans; Neoplasm Proteins/genetics; Placenta/metabolism; Pregnancy; Pregnancy Complications/physiopathology; RNA, Messenger/metabolism; Tandem Mass Spectrometry/methods; Up-Regulation; Ursodeoxycholic Acid/administration & dosage; Young Adult

Key words

bile acids; cholestasis of pregnancy; progesterone; ursodeoxycholic acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pregnancy Complications / Progesterone / Ursodeoxycholic Acid / Bile Acids and Salts / Cholestasis, Intrahepatic Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Pregnancy Language: En Journal: Br J Clin Pharmacol Year: 2015 Type: Article Affiliation country: Argentina

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