Serum protein profiling reveals baseline and pharmacodynamic biomarker signatures associated with clinical outcome in mCRC patients treated with chemotherapy ± cediranib.

Pommier, A J C; Shaw, R; Spencer, S K M; Morgan, S R; Hoff, P M; Robertson, J D; Barry, S T; Jürgensmeier, J M

Pommier, A J C; Shaw, R; Spencer, S K M; Morgan, S R; Hoff, P M; Robertson, J D; Barry, S T; Jürgensmeier, J M.

Affiliation

Pommier AJ; AstraZeneca, Oncology iMED, Alderley Park, Macclesfield SK10 4TG, UK.
Shaw R; AstraZeneca, Oncology iMED, Alderley Park, Macclesfield SK10 4TG, UK.
Spencer SK; AstraZeneca, Oncology iMED, Alderley Park, Macclesfield SK10 4TG, UK.
Morgan SR; AstraZeneca, Oncology iMED, Alderley Park, Macclesfield SK10 4TG, UK.
Hoff PM; 1] Instituto do Cancer do Estado de São Paulo, Universidade de São Paulo, São Paulo, Brazil [2] Centro de Oncologia, Hospital Sírio Libanês, São Paulo, Brazil.
Robertson JD; AstraZeneca, Oncology iMED, Alderley Park, Macclesfield SK10 4TG, UK.
Barry ST; AstraZeneca, Oncology iMED, Alderley Park, Macclesfield SK10 4TG, UK.
Jürgensmeier JM; 1] AstraZeneca, Oncology iMED, Alderley Park, Macclesfield SK10 4TG, UK [2] Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.

Br J Cancer ; 111(8): 1590-604, 2014 Oct 14.

Article in En | MEDLINE | ID: mdl-25121956

Subject(s)

Antineoplastic Agents/therapeutic use; Biomarkers, Tumor/blood; Blood Proteins/metabolism; Colorectal Neoplasms/drug therapy; Quinazolines/therapeutic use; Colorectal Neoplasms/blood; Colorectal Neoplasms/physiopathology; Humans; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Blood Proteins / Colorectal Neoplasms / Biomarkers, Tumor / Antineoplastic Agents Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Br J Cancer Year: 2014 Type: Article Affiliation country: United kingdom

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