Effect of p53 activity on the sensitivity of human glioblastoma cells to PARP-1 inhibitor in combination with topoisomerase I inhibitor or radiation.

Sabbatino, Francesco; Fusciello, Celeste; Somma, Domenico; Pacelli, Roberto; Poudel, Ravin; Pepin, David; Leonardi, Antonio; Carlomagno, Chiara; Della Vittoria Scarpati, Giuseppina; Ferrone, Soldano; Pepe, Stefano

Sabbatino, Francesco; Fusciello, Celeste; Somma, Domenico; Pacelli, Roberto; Poudel, Ravin; Pepin, David; Leonardi, Antonio; Carlomagno, Chiara; Della Vittoria Scarpati, Giuseppina; Ferrone, Soldano; Pepe, Stefano.

Affiliation

Sabbatino F; Department of Clinical Medicine and Surgery, University of Naples "Federico II", Via Sergio Pansini 5, Naples, Italy, 80131; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114.

Cytometry A ; 85(11): 953-61, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25182801

Subject(s)

Glioblastoma/drug therapy; Glioblastoma/radiotherapy; Poly(ADP-ribose) Polymerase Inhibitors; Topoisomerase I Inhibitors/pharmacology; Tumor Suppressor Protein p53/metabolism; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Proliferation/radiation effects; Combined Modality Therapy; DNA Damage/drug effects; DNA Repair/drug effects; DNA Topoisomerases, Type I/metabolism; Flow Cytometry; Humans; Poly (ADP-Ribose) Polymerase-1; Quinazolines/pharmacology; Radiation, Ionizing; Topotecan/pharmacology

Key words

PARP inhibitor; combinatorial strategy; glioblastoma; p53; radiotherapy; topotecan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tumor Suppressor Protein p53 / Glioblastoma / Topoisomerase I Inhibitors / Poly(ADP-ribose) Polymerase Inhibitors Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Cytometry A Year: 2014 Type: Article

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