A phase I and pharmacokinetic study of oral perifosine with different loading schedules in patients with refractory neoplasms.

Figg, William D; Monga, Manish; Headlee, Donna; Shah, Avni; Chau, Cindy H; Peer, Cody; Messman, Richard; Elsayed, Yusri A; Murgo, Anthony J; Melillo, Giovanni; Ryan, Qin C; Kalnitskiy, Mikhail; Senderowicz, Adrian M; Hollingshead, Melinda; Arbuck, Susan G; Sausville, Edward A

Figg, William D; Monga, Manish; Headlee, Donna; Shah, Avni; Chau, Cindy H; Peer, Cody; Messman, Richard; Elsayed, Yusri A; Murgo, Anthony J; Melillo, Giovanni; Ryan, Qin C; Kalnitskiy, Mikhail; Senderowicz, Adrian M; Hollingshead, Melinda; Arbuck, Susan G; Sausville, Edward A.

Affiliation

Figg WD; Medical Oncology Branch, National Cancer Institute, Bldg 10/Room 5A01, 9000 Rockville Pike, Bethesda, MD, 20892, USA, figgw@helix.nih.gov.

Cancer Chemother Pharmacol ; 74(5): 955-67, 2014 Nov.

Article in En | MEDLINE | ID: mdl-25183650

Subject(s)

Neoplasms/drug therapy; Neoplasms/metabolism; Phosphorylcholine/analogs & derivatives; Administration, Oral; Adult; Aged; Aged, 80 and over; Anorexia/chemically induced; Area Under Curve; Diarrhea/chemically induced; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Fatigue/chemically induced; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms/pathology; Phosphorylcholine/adverse effects; Phosphorylcholine/pharmacokinetics; Treatment Outcome; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphorylcholine / Neoplasms Type of study: Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Chemother Pharmacol Year: 2014 Type: Article

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