[Soft tissue tumors - the view of the molecular biologist]. / Nádory mekkých tkání ocima molekulárního patologa.
Cesk Patol
; 50(3): 132-40, 2014 Jul.
Article
in Cs
| MEDLINE
| ID: mdl-25186594
Soft tissue tumors (SSTs) constitute a broad spectrum of neoplasms with diverse biological properties. Rare or unusual types are often difficult to classify. Recent studies show, that a significant subset of SSTs including many types of sarcomas are associated with specific genetic changes such as chromosomal translocations producing chimeric genes, which play a role in the pathogenesis of SSTs. Because SSTs represent a diagnostically challenging group of tumors, molecular-genetic techniques (FISH or PCR) are useful as supplementary and/or confirmatory diagnostic tools. In the present paper we demonstrate the usefulness of a combined diagnostic approach using the tools of classical histopathology and immunohistochemistry together with the molecular diagnostic approach in selected nosologic entites.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Soft Tissue Neoplasms
/
Pathology, Molecular
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
Cs
Journal:
Cesk Patol
Year:
2014
Type:
Article