Effects of MEK inhibitors GSK1120212 and PD0325901 in vivo using 10-plex quantitative proteomics and phosphoproteomics.

Paulo, Joao A; McAllister, Fiona E; Everley, Robert A; Beausoleil, Sean A; Banks, Alexander S; Gygi, Steven P

Paulo, Joao A; McAllister, Fiona E; Everley, Robert A; Beausoleil, Sean A; Banks, Alexander S; Gygi, Steven P.

Affiliation

Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

Proteomics ; 15(2-3): 462-73, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25195567

Subject(s)

Benzamides/pharmacology; Diphenylamine/analogs & derivatives; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Phosphopeptides/analysis; Protein Kinase Inhibitors/pharmacology; Proteome/metabolism; Pyridones/pharmacology; Pyrimidinones/pharmacology; Amino Acid Sequence; Animals; Diphenylamine/pharmacology; Humans; Kidney/drug effects; Kidney/metabolism; Liver/drug effects; Liver/metabolism; MAP Kinase Signaling System/drug effects; Mice; Mitogen-Activated Protein Kinase Kinases/metabolism; Mitogen-Activated Protein Kinases/chemistry; Mitogen-Activated Protein Kinases/metabolism; Molecular Sequence Data; Pancreas/drug effects; Pancreas/metabolism; Phosphopeptides/metabolism; Phosphorylation/drug effects; Proteome/chemistry; Proteomics; Tandem Mass Spectrometry

Key words

Barttin; Cell biology; GSK1120212; Multiplexing; PD0325901; Phosphoproteomics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphopeptides / Pyridones / Pyrimidinones / Benzamides / Mitogen-Activated Protein Kinase Kinases / Proteome / Protein Kinase Inhibitors / Diphenylamine Limits: Animals / Humans Language: En Journal: Proteomics Journal subject: BIOQUIMICA Year: 2015 Type: Article Affiliation country: United States

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