Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice.

Calfa, Gaston; Li, Wei; Rutherford, John M; Pozzo-Miller, Lucas

Calfa, Gaston; Li, Wei; Rutherford, John M; Pozzo-Miller, Lucas.

Affiliation

Calfa G; Department of Neurobiology, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, Alabama.

Hippocampus ; 25(2): 159-68, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25209930

Subject(s)

CA3 Region, Hippocampal/physiopathology; Methyl-CpG-Binding Protein 2/deficiency; Methyl-CpG-Binding Protein 2/physiology; Neural Inhibition/physiology; Pyramidal Cells/physiopathology; Synapses/physiology; Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons/physiology; Male; Methyl-CpG-Binding Protein 2/genetics; Mice, Knockout; Microscopy, Confocal; Miniature Postsynaptic Potentials; Patch-Clamp Techniques; Receptors, AMPA/metabolism; Receptors, GABA-A/metabolism; Rett Syndrome; Tissue Culture Techniques

Key words

E/I balance; Hippocampus; MeCP2; Rett syndrome; intellectual disability

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Pyramidal Cells / Methyl-CpG-Binding Protein 2 / CA3 Region, Hippocampal / Neural Inhibition Limits: Animals Language: En Journal: Hippocampus Journal subject: CEREBRO Year: 2015 Type: Article

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