Ras regulates SCF(ß-TrCP) protein activity and specificity via its effector protein NORE1A.

Schmidt, M Lee; Donninger, Howard; Clark, Geoffrey J

Schmidt, M Lee; Donninger, Howard; Clark, Geoffrey J.

Affiliation

Schmidt ML; From the Molecular Targets Group, James Graham Brown Cancer Center, Departments of Biochemistry and Molecular Biology.
Donninger H; Medicine, and.
Clark GJ; Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky 40202 gjclar01@louisville.edu.

J Biol Chem ; 289(45): 31102-10, 2014 Nov 07.

Article in En | MEDLINE | ID: mdl-25217643

Subject(s)

Monomeric GTP-Binding Proteins/metabolism; SKP Cullin F-Box Protein Ligases/metabolism; ras Proteins/metabolism; Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; HEK293 Cells; Humans; Lung Neoplasms/metabolism; Proteasome Endopeptidase Complex/metabolism; Protein Binding; Signal Transduction; Substrate Specificity; beta Catenin/metabolism

Key words

E3 Ubiquitin Ligase; Oncogene; Ras Protein; Tumor Suppressor Gene; Wnt Signaling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ras Proteins / Monomeric GTP-Binding Proteins / SKP Cullin F-Box Protein Ligases Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2014 Type: Article

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