Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.

Eun, Jung Woo; Bae, Hyun Jin; Shen, Qingyu; Park, Se Jin; Kim, Hyung Seok; Shin, Woo Chan; Yang, Hee Doo; Jin, Chan Young; You, Jueng Soo; Kang, Hyun Joo; Kim, Hoguen; Ahn, Young Min; Park, Won Sang; Lee, Jung Young; Nam, Suk Woo

Eun, Jung Woo; Bae, Hyun Jin; Shen, Qingyu; Park, Se Jin; Kim, Hyung Seok; Shin, Woo Chan; Yang, Hee Doo; Jin, Chan Young; You, Jueng Soo; Kang, Hyun Joo; Kim, Hoguen; Ahn, Young Min; Park, Won Sang; Lee, Jung Young; Nam, Suk Woo.

Affiliation

Eun JW; Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Functional RNomics Research Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

J Appl Toxicol ; 35(2): 152-64, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25231249

Subject(s)

Chemical and Drug Induced Liver Injury/etiology; Animals; Biomarkers/analysis; Biomarkers/blood; Carbamazepine/toxicity; Chemical and Drug Induced Liver Injury/genetics; Chemical and Drug Induced Liver Injury/metabolism; Chlorpromazine/toxicity; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Enalapril/toxicity; Gene Expression/drug effects; Liver/chemistry; Liver/drug effects; Male; Oligonucleotide Array Sequence Analysis; Proteomics; Pyrazinamide/toxicity; Ranitidine/toxicity; Rats; Rats, Sprague-Dawley; Transcriptome/drug effects

Key words

Drug-induced liver injury; Gene expression; Hepatotoxicity; Molecular signature; Transcriptome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemical and Drug Induced Liver Injury Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Appl Toxicol Year: 2015 Type: Article

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