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Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of ß2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis.
Pericleous, Charis; Ruiz-Limón, Patricia; Romay-Penabad, Zurina; Marín, Ana Carrera; Garza-Garcia, Acely; Murfitt, Lucy; Driscoll, Paul C; Latchman, David S; Isenberg, David A; Giles, Ian; Ioannou, Yiannis; Rahman, Anisur; Pierangeli, Silvia S.
Affiliation
  • Pericleous C; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Ruiz-Limón P; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Romay-Penabad Z; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Marín AC; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Garza-Garcia A; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Murfitt L; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Driscoll PC; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Latchman DS; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Isenberg DA; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Giles I; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Ioannou Y; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Rahman A; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
  • Pierangeli SS; Centre for Rheumatology Research, Division of Medicine, University College London, London, UK, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA, Structural Biology, Medical Research Council National Institute for Medical Research and A
Rheumatology (Oxford) ; 54(4): 722-7, 2015 Apr.
Article in En | MEDLINE | ID: mdl-25273993
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Immunoglobulin G / Antiphospholipid Syndrome / Antibodies, Antiphospholipid / Disease Models, Animal / Beta 2-Glycoprotein I / Mice Type of study: Prognostic_studies Limits: Animals Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2015 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / Immunoglobulin G / Antiphospholipid Syndrome / Antibodies, Antiphospholipid / Disease Models, Animal / Beta 2-Glycoprotein I / Mice Type of study: Prognostic_studies Limits: Animals Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2015 Type: Article