The role of TLR8 signaling in acute myeloid leukemia differentiation.

Ignatz-Hoover, James J; Wang, Huaiyu; Moreton, Stephen A; Chakrabarti, Amit; Agarwal, Mukesh K; Sun, Kevin; Gupta, Kalpana; Wald, David N

Ignatz-Hoover, James J; Wang, Huaiyu; Moreton, Stephen A; Chakrabarti, Amit; Agarwal, Mukesh K; Sun, Kevin; Gupta, Kalpana; Wald, David N.

Affiliation

Ignatz-Hoover JJ; Department of Pathology, Case Western Reserve University, Cleveland OH.
Wang H; Department of Pathology, Case Western Reserve University, Cleveland OH.
Moreton SA; Department of Hematology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Chakrabarti A; Department of Pathology, Case Western Reserve University, Cleveland OH.
Agarwal MK; Invenio Therapeutics, Cleveland, OH.
Sun K; Invenio Therapeutics, Cleveland, OH.
Gupta K; Department of Pathology, Case Western Reserve University, Cleveland OH.
Wald DN; Department of Pathology, Case Western Reserve University, Cleveland OH.

Leukemia ; 29(4): 918-926, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25283842

Subject(s)

Antineoplastic Agents/pharmacology; Gene Expression Regulation, Leukemic; Imidazoles/pharmacology; Leukemia, Myeloid, Acute/drug therapy; Signal Transduction/drug effects; Toll-Like Receptor 8/agonists; Animals; Bone Marrow Cells/drug effects; Bone Marrow Cells/metabolism; Bone Marrow Cells/pathology; Cell Differentiation; Female; HL-60 Cells; Humans; Leukemia, Myeloid, Acute/genetics; Leukemia, Myeloid, Acute/metabolism; Leukemia, Myeloid, Acute/pathology; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Mice; Mice, Inbred NOD; Mice, SCID; Myeloid Differentiation Factor 88/genetics; Myeloid Differentiation Factor 88/metabolism; Signal Transduction/genetics; Toll-Like Receptor 7/genetics; Toll-Like Receptor 7/metabolism; Toll-Like Receptor 8/genetics; Toll-Like Receptor 8/metabolism; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Signal Transduction / Gene Expression Regulation, Leukemic / Toll-Like Receptor 8 / Imidazoles / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2015 Type: Article

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