Nerve growth factor and proNGF simultaneously promote symmetric self-renewal, quiescence, and epithelial to mesenchymal transition to enlarge the breast cancer stem cell compartment.

Tomellini, Elisa; Touil, Yasmine; Lagadec, Chann; Julien, Sylvain; Ostyn, Pauline; Ziental-Gelus, Nathalie; Meignan, Samuel; Lengrand, Justine; Adriaenssens, Eric; Polakowska, Renata; Le Bourhis, Xuefen

Tomellini, Elisa; Touil, Yasmine; Lagadec, Chann; Julien, Sylvain; Ostyn, Pauline; Ziental-Gelus, Nathalie; Meignan, Samuel; Lengrand, Justine; Adriaenssens, Eric; Polakowska, Renata; Le Bourhis, Xuefen.

Affiliation

Tomellini E; Inserm U908, Villeneuve d'Ascq, France; Université Lille 1, Villeneuve d'Ascq, France; Inserm U837 Jean-Pierre Aubert Research Center, Institut pour la Recherche sur le Cancer de Lille (IRCL), Lille, France.

Stem Cells ; 33(2): 342-53, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25286822

Subject(s)

Autocrine Communication; Breast Neoplasms/metabolism; Cell Proliferation; Epithelial-Mesenchymal Transition; Neoplasm Proteins/metabolism; Neoplastic Stem Cells/metabolism; Nerve Growth Factor/metabolism; Protein Precursors/metabolism; Stem Cell Niche; Animals; Breast Neoplasms/pathology; Female; Humans; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplastic Stem Cells/pathology; Nerve Tissue Proteins/metabolism; Receptors, Nerve Growth Factor/metabolism

Key words

Breast cancer stem cells; Nerve growth factor; p75NTR; proNGF

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Precursors / Neoplastic Stem Cells / Breast Neoplasms / Autocrine Communication / Nerve Growth Factor / Cell Proliferation / Stem Cell Niche / Epithelial-Mesenchymal Transition / Neoplasm Proteins Limits: Animals / Female / Humans Language: En Journal: Stem Cells Year: 2015 Type: Article Affiliation country: France

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