A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling.

Chung, Jon H; Larsen, Andrew R; Chen, Evan; Bunz, Fred

Chung, Jon H; Larsen, Andrew R; Chen, Evan; Bunz, Fred.

Affiliation

Chung JH; From the Department of Radiation Oncology and Molecular Radiation Sciences, The Kimmel Cancer Center at Johns Hopkins, Baltimore, Maryland 21231.
Larsen AR; From the Department of Radiation Oncology and Molecular Radiation Sciences, The Kimmel Cancer Center at Johns Hopkins, Baltimore, Maryland 21231.
Chen E; From the Department of Radiation Oncology and Molecular Radiation Sciences, The Kimmel Cancer Center at Johns Hopkins, Baltimore, Maryland 21231.
Bunz F; From the Department of Radiation Oncology and Molecular Radiation Sciences, The Kimmel Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 fredbunz@jhmi.edu.

J Biol Chem ; 289(47): 33020-31, 2014 Nov 21.

Article in En | MEDLINE | ID: mdl-25296753

Subject(s)

Hedgehog Proteins/genetics; Repressor Proteins/genetics; Signal Transduction/genetics; Transcriptional Activation; Tumor Suppressor Protein p53/genetics; Binding Sites/genetics; Cell Line, Tumor; Colorectal Neoplasms/genetics; Colorectal Neoplasms/metabolism; Colorectal Neoplasms/pathology; Down-Regulation; HCT116 Cells; HEK293 Cells; Hedgehog Proteins/metabolism; Humans; Molecular Sequence Data; Mutation; Promoter Regions, Genetic/genetics; Protein Binding; RNA Interference; Repressor Proteins/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53/metabolism

Key words

DNA Damage Response; Sonic Hedgehog (SHH); Tumor Cell Biology; Tumor Suppressor Gene; p53

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Signal Transduction / Transcriptional Activation / Tumor Suppressor Protein p53 / Hedgehog Proteins Limits: Humans Language: En Journal: J Biol Chem Year: 2014 Type: Article

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