Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation.
Xenotransplantation
; 22(2): 85-94, 2015.
Article
in En
| MEDLINE
| ID: mdl-25308416
ABSTRACT
Human beings do not synthesize the glycolyl form of the sialic acid (Neu5Gc) and only express the acetylated form of the sugar, whereas a diet-based intake of Neu5Gc provokes a natural immunization and production of anti-Neu5Gc antibodies in human serum. However, Neu5Gc is expressed on mammal glycoproteins and glycolipids in most organs and cells. We review here the relevance of Neu5Gc and anti-Neu5Gc antibodies in the context of xenotransplantation and the use of animal-derived molecules and products, as well as the possible consequences of a long-term exposure to anti-Neu5Gc antibodies in recipients of xenografts. In addition, the importance of an accurate estimation of the anti-Neu5Gc response following xenotransplantation and the future contribution of knockout animals mimicking the human situation are also assessed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transplantation, Heterologous
/
Antibodies, Heterophile
/
Neuraminic Acids
Limits:
Animals
/
Humans
Language:
En
Journal:
Xenotransplantation
Journal subject:
TRANSPLANTE
Year:
2015
Type:
Article
Affiliation country:
France