Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis.

Tada, Satoru; Okuno, Tatsusada; Hitoshi, Yasumichi; Yasui, Teruhito; Honorat, Josephe Archie; Takata, Kazushiro; Koda, Toru; Shimagami, Hiroshi; Chi-Jing, Choong; Namba, Akiko; Sugimoto, Tomoyuki; Sakoda, Saburo; Mochizuki, Hideki; Kikutani, Hitoshi; Nakatsuji, Yuji

Tada, Satoru; Okuno, Tatsusada; Hitoshi, Yasumichi; Yasui, Teruhito; Honorat, Josephe Archie; Takata, Kazushiro; Koda, Toru; Shimagami, Hiroshi; Chi-Jing, Choong; Namba, Akiko; Sugimoto, Tomoyuki; Sakoda, Saburo; Mochizuki, Hideki; Kikutani, Hitoshi; Nakatsuji, Yuji.

J Neuroinflammation ; 11: 179, 2014 Oct 19.

Article in En | MEDLINE | ID: mdl-25326688

Subject(s)

Amyotrophic Lateral Sclerosis/pathology; Enzyme Inhibitors/pharmacology; Janus Kinase 2/antagonists & inhibitors; Microglia/drug effects; Nerve Degeneration/prevention & control; Animals; Disease Models, Animal; Flow Cytometry; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration/enzymology; Nerve Degeneration/immunology; Spinal Cord/drug effects; Spinal Cord/immunology; Spinal Cord/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microglia / Enzyme Inhibitors / Janus Kinase 2 / Amyotrophic Lateral Sclerosis / Nerve Degeneration Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2014 Type: Article

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