The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation.

Miyata, Yoshihiko; Shibata, Takeshi; Aoshima, Masato; Tsubata, Takuichi; Nishida, Eisuke

Miyata, Yoshihiko; Shibata, Takeshi; Aoshima, Masato; Tsubata, Takuichi; Nishida, Eisuke.

Affiliation

Miyata Y; From the Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan and ymiyata@lif.kyoto-u.ac.jp.
Shibata T; K.K. AB Sciex Japan, Tokyo 140-0001, Japan.
Aoshima M; K.K. AB Sciex Japan, Tokyo 140-0001, Japan.
Tsubata T; K.K. AB Sciex Japan, Tokyo 140-0001, Japan.
Nishida E; From the Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan and.

J Biol Chem ; 289(48): 33320-32, 2014 Nov 28.

Article in En | MEDLINE | ID: mdl-25342745

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Cell Nucleus/metabolism; Chaperonin Containing TCP-1/metabolism; Protein Serine-Threonine Kinases/metabolism; Protein-Tyrosine Kinases/metabolism; Active Transport, Cell Nucleus/physiology; Adaptor Proteins, Signal Transducing/genetics; Animals; COS Cells; Cell Nucleus/genetics; Chaperonin Containing TCP-1/genetics; Chlorocebus aethiops; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Humans; MAP Kinase Kinase Kinase 1/genetics; MAP Kinase Kinase Kinase 1/metabolism; Models, Molecular; Protein Binding; Protein Serine-Threonine Kinases/genetics; Protein Structure, Secondary; Protein-Tyrosine Kinases/genetics; Structure-Activity Relationship; Dyrk Kinases

Key words

DYRK1A; Heat Shock Protein (HSP); Molecular Chaperone; Nuclear Translocation; Phosphoproteomics; Protein Phosphorylation; TCP1; TRiC/CCT; WD40 Repeat; WDR68

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Cell Nucleus / Protein Serine-Threonine Kinases / Adaptor Proteins, Signal Transducing / Chaperonin Containing TCP-1 Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2014 Type: Article

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