Simultaneous determination of sarpogrelate and its active metabolite in human plasma by liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study.

Park, Jung Bae; Bae, Soo Kyung; Bae, Soo Hyeon; Oh, Euichaul

Park, Jung Bae; Bae, Soo Kyung; Bae, Soo Hyeon; Oh, Euichaul.

Affiliation

Park JB; College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, Republic of Korea.

J Sep Sci ; 38(1): 42-9, 2015 Jan.

Article in En | MEDLINE | ID: mdl-25354353

Subject(s)

Chromatography, High Pressure Liquid/methods; Serotonin Antagonists/pharmacokinetics; Succinates/pharmacokinetics; Humans; Male; Serotonin Antagonists/blood; Serotonin Antagonists/metabolism; Succinates/blood; Succinates/metabolism; Tandem Mass Spectrometry/methods

Key words

Active metabolites; human plasma; method validation; pharmacokinetics; sarpogrelate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serotonin Antagonists / Succinates / Chromatography, High Pressure Liquid Type of study: Evaluation_studies Limits: Humans / Male Language: En Journal: J Sep Sci Year: 2015 Type: Article

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