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A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory.
Swadling, Leo; Capone, Stefania; Antrobus, Richard D; Brown, Anthony; Richardson, Rachel; Newell, Evan W; Halliday, John; Kelly, Christabel; Bowen, Dan; Fergusson, Joannah; Kurioka, Ayako; Ammendola, Virginia; Del Sorbo, Mariarosaria; Grazioli, Fabiana; Esposito, Maria Luisa; Siani, Loredana; Traboni, Cinzia; Hill, Adrian; Colloca, Stefano; Davis, Mark; Nicosia, Alfredo; Cortese, Riccardo; Folgori, Antonella; Klenerman, Paul; Barnes, Eleanor.
Affiliation
  • Swadling L; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK.
  • Capone S; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy.
  • Antrobus RD; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Brown A; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK.
  • Richardson R; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK.
  • Newell EW; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA. Singapore Immunology Network, Singapore 138648, Singapore.
  • Halliday J; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. National Institute for Health Research Oxford Biomedical Research Centre, and Translational Gastroenterology Unit, Oxford OX3 7LE, UK.
  • Kelly C; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. National Institute for Health Research Oxford Biomedical Research Centre, and Translational Gastroenterology Unit, Oxford OX3 7LE, UK.
  • Bowen D; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK.
  • Fergusson J; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK.
  • Kurioka A; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK.
  • Ammendola V; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy.
  • Del Sorbo M; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy.
  • Grazioli F; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy.
  • Esposito ML; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy.
  • Siani L; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy.
  • Traboni C; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy.
  • Hill A; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Colloca S; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy.
  • Davis M; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
  • Nicosia A; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy. CEINGE, via Gaetano Salvatore 486, 80145 Naples, Italy. Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Cortese R; Okairos AG, 4051 Basel, Switzerland.
  • Folgori A; ReiThera Srl (ex Okairos), Viale Città d'Europa 679, 00144 Rome, Italy.
  • Klenerman P; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. National Institute for Health Research Oxford Biomedical Research Centre, and Translational Gastroenterology Unit, Oxford OX3 7LE, UK.
  • Barnes E; Nuffield Department of Medicine, University of Oxford, Oxford OX1 3SY, UK. The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK. National Institute for Health Research Oxford Biomedical Research Centre, and Translational Gastroenterology Unit, Oxford OX3 7LE, UK. ellie.barnes@ndm.ox.ac.uk.
Sci Transl Med ; 6(261): 261ra153, 2014 Nov 05.
Article in En | MEDLINE | ID: mdl-25378645
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Hepatitis Vaccines / Viral Vaccines / CD4-Positive T-Lymphocytes / Adenoviridae / Vaccination / Hepatitis C / Hepacivirus / CD8-Positive T-Lymphocytes / Immunologic Memory Type of study: Diagnostic_studies Limits: Animals / Humans Country/Region as subject: Europa Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2014 Type: Article Affiliation country: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Hepatitis Vaccines / Viral Vaccines / CD4-Positive T-Lymphocytes / Adenoviridae / Vaccination / Hepatitis C / Hepacivirus / CD8-Positive T-Lymphocytes / Immunologic Memory Type of study: Diagnostic_studies Limits: Animals / Humans Country/Region as subject: Europa Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2014 Type: Article Affiliation country: United kingdom