Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.

Colón-Bolea, Paula; Crespo, Piero

Colón-Bolea, Paula; Crespo, Piero.

Affiliation

Colón-Bolea P; Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC) - Universidad de Cantabria, Santander, Spain.

Bioessays ; 36(12): 1162-9, 2014 Dec.

Article in En | MEDLINE | ID: mdl-25382779

Subject(s)

Adenocarcinoma/metabolism; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase/metabolism; Lung Neoplasms/metabolism; Lysine/metabolism; MAP Kinase Kinase Kinases/metabolism; Pancreatic Neoplasms/metabolism; Adenocarcinoma/drug therapy; Adenocarcinoma/genetics; Adenocarcinoma/pathology; Antineoplastic Agents/therapeutic use; Histone-Lysine N-Methyltransferase/genetics; Humans; Lung Neoplasms/drug therapy; Lung Neoplasms/genetics; Lung Neoplasms/pathology; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases/genetics; Methylation; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/genetics; Mitogen-Activated Protein Kinase 3/metabolism; Pancreatic Neoplasms/drug therapy; Pancreatic Neoplasms/genetics; Pancreatic Neoplasms/pathology; Protein Binding; Protein Kinase Inhibitors/therapeutic use; Protein Phosphatase 2/genetics; Protein Phosphatase 2/metabolism; Proto-Oncogene Proteins p21(ras)/genetics; Proto-Oncogene Proteins p21(ras)/metabolism; Signal Transduction

Key words

ERK; MAP3K2; Ras; SMYD3; cancer; lysine methylation; lysine methyltransferases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Adenocarcinoma / Gene Expression Regulation, Neoplastic / Histone-Lysine N-Methyltransferase / MAP Kinase Kinase Kinases / Lung Neoplasms / Lysine Limits: Humans Language: En Journal: Bioessays Journal subject: BIOLOGIA / BIOLOGIA MOLECULAR Year: 2014 Type: Article Affiliation country: Spain

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