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Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity.
Wagner, Koen; Kwakkenbos, Mark J; Claassen, Yvonne B; Maijoor, Kelly; Böhne, Martino; van der Sluijs, Koenraad F; Witte, Martin D; van Zoelen, Diana J; Cornelissen, Lisette A; Beaumont, Tim; Bakker, Arjen Q; Ploegh, Hidde L; Spits, Hergen.
Affiliation
  • Wagner K; AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands;
  • Kwakkenbos MJ; AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands;
  • Claassen YB; AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands;
  • Maijoor K; AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands;
  • Böhne M; AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands;
  • van der Sluijs KF; Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands;
  • Witte MD; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; and.
  • van Zoelen DJ; Department of Virology, Central Veterinary Institute, Wageningen University and Research Centre, 8200 AB Lelystad, The Netherlands.
  • Cornelissen LA; Department of Virology, Central Veterinary Institute, Wageningen University and Research Centre, 8200 AB Lelystad, The Netherlands.
  • Beaumont T; AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands;
  • Bakker AQ; AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands;
  • Ploegh HL; Whitehead Institute for Biomedical Research, Cambridge, MA 02142; and.
  • Spits H; AIMM Therapeutics, 1105 BA Amsterdam, The Netherlands; hspits@aimmtherapeutics.com.
Proc Natl Acad Sci U S A ; 111(47): 16820-5, 2014 Nov 25.
Article in En | MEDLINE | ID: mdl-25385586
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza A virus / Antibodies, Bispecific / Click Chemistry Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Influenza A virus / Antibodies, Bispecific / Click Chemistry Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article