Energy status and HIF signalling in chorionic villi show no evidence of hypoxic stress during human early placental development.

Cindrova-Davies, T; van Patot, M Tissot; Gardner, L; Jauniaux, E; Burton, G J; Charnock-Jones, D S

Cindrova-Davies, T; van Patot, M Tissot; Gardner, L; Jauniaux, E; Burton, G J; Charnock-Jones, D S.

Affiliation

Cindrova-Davies T; Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.
van Patot MT; Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.
Gardner L; Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.
Jauniaux E; Academic Department of Obstetrics and Gynaecology, Royal Free and University College, London, UK.
Burton GJ; Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK gjb2@cam.ac.uk.
Charnock-Jones DS; Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge CB2 0SW, UK National Institute for Health Research, Cambridge Comprehensive Biomedical

Mol Hum Reprod ; 21(3): 296-308, 2015 Mar.

Article in En | MEDLINE | ID: mdl-25391298

Subject(s)

Basic Helix-Loop-Helix Transcription Factors/metabolism; Chorionic Villi/drug effects; Energy Metabolism/drug effects; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Oxygen/pharmacology; Adenosine Diphosphate/metabolism; Adenosine Triphosphate/metabolism; Adult; Basic Helix-Loop-Helix Transcription Factors/genetics; Cell Hypoxia; Chorionic Villi/growth & development; Chorionic Villi/metabolism; Energy Metabolism/genetics; Female; Gene Expression Regulation, Developmental; Glucose Transporter Type 3/genetics; Glucose Transporter Type 3/metabolism; Humans; Hydrogen Peroxide/pharmacology; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Imidazoles/pharmacology; Membrane Proteins/genetics; Membrane Proteins/metabolism; Placentation/physiology; Pregnancy; Pregnancy Trimesters; Primary Cell Culture; Signal Transduction; Transcription, Genetic; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

HIF-1α; energy status; first trimester; metabolomics; placenta

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Chorionic Villi / Energy Metabolism / Basic Helix-Loop-Helix Transcription Factors / Hypoxia-Inducible Factor 1, alpha Subunit Limits: Adult / Female / Humans / Pregnancy Language: En Journal: Mol Hum Reprod Journal subject: BIOLOGIA MOLECULAR / MEDICINA REPRODUTIVA Year: 2015 Type: Article Affiliation country: United kingdom

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