Shading the TRF2 recruiting function: a new horizon in drug development.

Di Maro, Salvatore; Zizza, Pasquale; Salvati, Erica; De Luca, Viviana; Capasso, Clemente; Fotticchia, Iolanda; Pagano, Bruno; Marinelli, Luciana; Gilson, Eric; Novellino, Ettore; Cosconati, Sandro; Biroccio, Annamaria

Di Maro, Salvatore; Zizza, Pasquale; Salvati, Erica; De Luca, Viviana; Capasso, Clemente; Fotticchia, Iolanda; Pagano, Bruno; Marinelli, Luciana; Gilson, Eric; Novellino, Ettore; Cosconati, Sandro; Biroccio, Annamaria.

Affiliation

Di Maro S; DiSTABiF, Second University of Naples , Caserta, Italy.

J Am Chem Soc ; 136(48): 16708-11, 2014 Dec 03.

Article in En | MEDLINE | ID: mdl-25393214

ABSTRACT

The shelterin protein TRF2 has come to the limelight for its role in telomere maintenance and tumorigenesis. Herein, the application of rational design and synthesis allowed identifying the first TRF2TRFH binder able to elicit a marked DNA damage response in cancer cells. This work paves the way for the unprecedented employment of a chemical tool to finely tune specific mechanisms underlying telomere maintenance.

Subject(s)

Drug Design; Peptides, Cyclic/pharmacology; Telomeric Repeat Binding Protein 2/antagonists & inhibitors; Humans; Models, Molecular; Peptides, Cyclic/chemical synthesis; Peptides, Cyclic/chemistry; Telomeric Repeat Binding Protein 2/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Drug Design / Telomeric Repeat Binding Protein 2 Limits: Humans Language: En Journal: J Am Chem Soc Year: 2014 Type: Article Affiliation country: Italy

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