Noise decomposition of intracellular biochemical signaling networks using nonequivalent reporters.

Rhee, Alex; Cheong, Raymond; Levchenko, Andre

Rhee, Alex; Cheong, Raymond; Levchenko, Andre.

Affiliation

Rhee A; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218; and.
Cheong R; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218; and.
Levchenko A; Yale Systems Biology Institute and Department of Biomedical Engineering, Yale University, New Haven, CT 06520 andre.levchenko@yale.edu.

Proc Natl Acad Sci U S A ; 111(48): 17330-5, 2014 Dec 02.

Article in En | MEDLINE | ID: mdl-25404303

Subject(s)

Algorithms; Biochemical Phenomena/physiology; Intracellular Space/metabolism; Models, Biological; Signal Transduction/physiology; 3T3 Cells; Activating Transcription Factor 2/metabolism; Animals; Cysteine Endopeptidases/genetics; Cysteine Endopeptidases/metabolism; Feedback, Physiological/drug effects; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Intracellular Space/drug effects; JNK Mitogen-Activated Protein Kinases/metabolism; Mice; Microscopy, Fluorescence; Mutation; NF-kappa B/metabolism; Receptors, Tumor Necrosis Factor/metabolism; Signal Transduction/drug effects; Tumor Necrosis Factor alpha-Induced Protein 3; Tumor Necrosis Factors/pharmacology

Key words

analysis of variance; extrinsic noise; intrinsic noise; noise decomposition; signal transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biochemical Phenomena / Algorithms / Signal Transduction / Intracellular Space / Models, Biological Type of study: Prognostic_studies Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2014 Type: Article

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