Spontaneous bone metastases in a preclinical orthotopic model of invasive lobular carcinoma; the effect of pharmacological targeting TGFß receptor I kinase.

Buijs, Jeroen T; Matula, Kasia M; Cheung, Henry; Kruithof-de Julio, Marianna; van der Mark, Maaike H; Snoeks, Thomas J; Cohen, Ron; Corver, Willem E; Mohammad, Khalid S; Jonkers, Jos; Guise, Theresa A; van der Pluijm, Gabri

Buijs, Jeroen T; Matula, Kasia M; Cheung, Henry; Kruithof-de Julio, Marianna; van der Mark, Maaike H; Snoeks, Thomas J; Cohen, Ron; Corver, Willem E; Mohammad, Khalid S; Jonkers, Jos; Guise, Theresa A; van der Pluijm, Gabri.

Affiliation

Buijs JT; Department of Urology, Leiden University Medical Centre, Leiden, The Netherlands.

J Pathol ; 235(5): 745-59, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25421310

Subject(s)

Bone Neoplasms/secondary; Breast Neoplasms/pathology; Carcinoma, Lobular/secondary; Mammary Neoplasms, Experimental/pathology; Protein Kinase Inhibitors/toxicity; Protein Serine-Threonine Kinases/antagonists & inhibitors; Pteridines/toxicity; Receptors, Transforming Growth Factor beta/antagonists & inhibitors; Animals; Apoptosis/drug effects; Bone Neoplasms/enzymology; Bone Neoplasms/genetics; Breast Neoplasms/chemically induced; Breast Neoplasms/enzymology; Breast Neoplasms/genetics; Carcinoma, Lobular/chemically induced; Carcinoma, Lobular/enzymology; Carcinoma, Lobular/genetics; Cdh1 Proteins/deficiency; Cdh1 Proteins/genetics; Cell Line, Tumor; Cell Proliferation/drug effects; Female; Mammary Neoplasms, Experimental/chemically induced; Mammary Neoplasms, Experimental/enzymology; Mammary Neoplasms, Experimental/genetics; Mice, Knockout; Neoplasm Micrometastasis; Protein Serine-Threonine Kinases/metabolism; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta/metabolism; Signal Transduction/drug effects; Time Factors; Transfection; Tumor Burden/drug effects; Tumor Suppressor Protein p53/deficiency; Tumor Suppressor Protein p53/genetics

Key words

SD-208; TGFß; breast cancer; invasive lobular carcinoma; metastasis; minimal residual disease; mouse model; receptor I kinase inhibitor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pteridines / Bone Neoplasms / Breast Neoplasms / Protein Serine-Threonine Kinases / Receptors, Transforming Growth Factor beta / Carcinoma, Lobular / Protein Kinase Inhibitors / Mammary Neoplasms, Experimental Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pathol Year: 2015 Type: Article Affiliation country: Netherlands

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