RNA interference targeting hypoxia-inducible factor 1&#945; via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model.

Gillespie, David L; Aguirre, Maria T; Ravichandran, Sandhya; Leishman, Lisa L; Berrondo, Claudia; Gamboa, Joseph T; Wang, Libo; King, Rose; Wang, Xuli; Tan, Mingqian; Malamas, Anthony; Lu, Zheng-Rong; Jensen, Randy L

RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model.

Gillespie, David L; Aguirre, Maria T; Ravichandran, Sandhya; Leishman, Lisa L; Berrondo, Claudia; Gamboa, Joseph T; Wang, Libo; King, Rose; Wang, Xuli; Tan, Mingqian; Malamas, Anthony; Lu, Zheng-Rong; Jensen, Randy L.

Affiliation

Gillespie DL; Huntsman Cancer Institute and Department of Neurosurgery and.

J Neurosurg ; 122(2): 331-41, 2015 Feb.

Article in En | MEDLINE | ID: mdl-25423275

Subject(s)

Brain Neoplasms/pathology; Cell Proliferation/drug effects; Dipeptides/pharmacology; Glioma/pathology; Hypoxia-Inducible Factor 1, alpha Subunit/drug effects; RNA Interference; RNA, Small Interfering/pharmacology; Animals; Brain Neoplasms/mortality; Brain Neoplasms/prevention & control; Carbonic Anhydrase IX; Carbonic Anhydrases/metabolism; Dipeptides/therapeutic use; Disease Models, Animal; Gene Knockdown Techniques; Glioma/mortality; Glioma/prevention & control; Glucose Transporter Type 1/metabolism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Ki-67 Antigen/metabolism; Mice; Mice, Nude; Proto-Oncogene Proteins c-met/metabolism; RNA, Small Interfering/therapeutic use; Survival Rate; Vascular Endothelial Growth Factor A/metabolism; Xenograft Model Antitumor Assays

Key words

CA-IX = carbonic anhydrase-IX; CED = convection-enhanced delivery; DAB = 3,3'-diaminobenzidine tetrahydrochloride; DCA = dichloroacetate; EHCO = 1-(aminoethyl)iminobis[N-(oleicylcysteinylhistinyl-1-aminoethyl)propionamide]; GFP = green fluorescent protein; GLUT-1 = glucose transporter 1; HIF-1α; HIF-1α = hypoxia-inducible factor 1α; IHC = immunohistochemistry; MVD = microvascular density; PEG = polyethylene glycol; PI = proliferation index; RNA interference; RNAi = RNA interference; VEGF = vascular endothelial growth factor; glioma; intracranial; knockdown; mouse; oncology; siRNA; siRNA = small interfering RNA; tumor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / RNA, Small Interfering / RNA Interference / Cell Proliferation / Dipeptides / Hypoxia-Inducible Factor 1, alpha Subunit / Glioma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Neurosurg Year: 2015 Type: Article

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