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Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).
Trani, Giancarlo; Barker, John J; Bromidge, Steven M; Brookfield, Frederick A; Burch, Jason D; Chen, Yuan; Eigenbrot, Charles; Heifetz, Alexander; Ismaili, M Hicham A; Johnson, Adam; Krülle, Thomas M; MacKinnon, Colin H; Maghames, Rosemary; McEwan, Paul A; Montalbetti, Christian A G N; Ortwine, Daniel F; Pérez-Fuertes, Yolanda; Vaidya, Darshan G; Wang, Xiaolu; Zarrin, Ali A; Pei, Zhonghua.
Affiliation
  • Trani G; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK. Electronic address: Giancarlo.Trani@evotec.com.
  • Barker JJ; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Bromidge SM; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Brookfield FA; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Burch JD; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Chen Y; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Eigenbrot C; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Heifetz A; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Ismaili MHA; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Johnson A; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Krülle TM; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • MacKinnon CH; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Maghames R; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • McEwan PA; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Montalbetti CAGN; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Ortwine DF; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Pérez-Fuertes Y; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Vaidya DG; Discovery Chemistry, Evotec UK Ltd, 114 Innovation Drive, Milton Park, Abingdon, OX14 4RZ, UK.
  • Wang X; Discovery Biology, Evotec AG, Manfred Eigen Campus, Essener Bogen 7, D-22419 Hamburg, Germany.
  • Zarrin AA; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Pei Z; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Bioorg Med Chem Lett ; 24(24): 5818-5823, 2014 Dec 15.
Article in En | MEDLINE | ID: mdl-25455497
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Protein-Tyrosine Kinases / Drug Design / Protein Kinase Inhibitors Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article
Fulltext
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Protein-Tyrosine Kinases / Drug Design / Protein Kinase Inhibitors Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article