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G226, a new epipolythiodioxopiperazine derivative, triggers DNA damage and apoptosis in human cancer cells in vitro via ROS generation.
He, Peng-xing; Zhang, Jie; Che, Yong-sheng; He, Qiao-jun; Chen, Yi; Ding, Jian.
Affiliation
  • He PX; Institute of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
  • Zhang J; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Che YS; Beijing Institute of Pharmacology & Toxicology, Beijing 100190, China.
  • He QJ; Institute of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
  • Chen Y; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Ding J; Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Acta Pharmacol Sin ; 35(12): 1546-55, 2014 Dec.
Article in En | MEDLINE | ID: mdl-25468822
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / DNA Damage / Reactive Oxygen Species / Apoptosis / Oxidative Stress / Disulfides / Diketopiperazines / Topoisomerase II Inhibitors / Neoplasms Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2014 Type: Article Affiliation country: China
Fulltext
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XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / DNA Damage / Reactive Oxygen Species / Apoptosis / Oxidative Stress / Disulfides / Diketopiperazines / Topoisomerase II Inhibitors / Neoplasms Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2014 Type: Article Affiliation country: China