Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity.

Baumann, Sascha; Herrmann, Jennifer; Raju, Ritesh; Steinmetz, Heinrich; Mohr, Kathrin I; Hüttel, Stephan; Harmrolfs, Kirsten; Stadler, Marc; Müller, Rolf

Baumann, Sascha; Herrmann, Jennifer; Raju, Ritesh; Steinmetz, Heinrich; Mohr, Kathrin I; Hüttel, Stephan; Harmrolfs, Kirsten; Stadler, Marc; Müller, Rolf.

Affiliation

Baumann S; Abteilung Mikrobielle Naturstoffe, Helmholtz Institut für Pharmazeutische Forschung Saarland, Helmholtz Zentrum für Infektionsforschung, Universität des Saarlandes, Campus C2.3, 66123 Saarbrücken (Germany); Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig (Germany).

Angew Chem Int Ed Engl ; 53(52): 14605-9, 2014 Dec 22.

Article in En | MEDLINE | ID: mdl-25510965

Subject(s)

Anti-Bacterial Agents/chemistry; Asparagine/analogs & derivatives; Bacterial Proteins/antagonists & inhibitors; DNA Topoisomerases, Type I/chemistry; Myxococcales/enzymology; Nitro Compounds/chemistry; Topoisomerase Inhibitors/chemistry; Anti-Bacterial Agents/biosynthesis; Anti-Bacterial Agents/pharmacology; Asparagine/chemical synthesis; Asparagine/chemistry; Asparagine/pharmacology; Bacterial Proteins/metabolism; DNA Topoisomerases, Type I/metabolism; Gram-Negative Bacteria/drug effects; Gram-Positive Bacteria/drug effects; Microbial Sensitivity Tests; Nitro Compounds/chemical synthesis; Nitro Compounds/pharmacology; Peptide Synthases/metabolism; Topoisomerase Inhibitors/metabolism; Topoisomerase Inhibitors/pharmacology

Key words

NRPS; antibiotics; myxobacteria; natural products; topoisomerase inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asparagine / Bacterial Proteins / Myxococcales / DNA Topoisomerases, Type I / Topoisomerase Inhibitors / Anti-Bacterial Agents / Nitro Compounds Language: En Journal: Angew Chem Int Ed Engl Year: 2014 Type: Article

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