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IL-17 cuts to the chase in colon cancer.
Ernst, Matthias; Putoczki, Tracy.
Affiliation
  • Ernst M; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville VIC 3052, Australia. Electronic address: matthias.ernst@onjcri.org.au.
  • Putoczki T; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville VIC 3052, Australia. Electronic address: tracy.putoczki@wehi.edu.au.
Immunity ; 41(6): 880-2, 2014 Dec 18.
Article in En | MEDLINE | ID: mdl-25526302
ABSTRACT
Although interleukin-17A (IL-17A) facilitates colon cancer development, its target cells remain elusive. In this issue of Immunity, Wang et al. (2014) now demonstrate that IL-17A receptors on the intestinal epithelium promote progression of APC mutant adenomas associated with IL-6 expression and that IL-17A confers chemotherapy resistance.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Colonic Neoplasms / Enterocytes / Receptors, Interleukin-17 Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Colonic Neoplasms / Enterocytes / Receptors, Interleukin-17 Limits: Animals / Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2014 Type: Article