Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis.

Saferali, Aabida; Obeidat, Ma'en; Bérubé, Jean-Christophe; Lamontagne, Maxime; Bossé, Yohan; Laviolette, Michel; Hao, Ke; Nickle, David C; Timens, Wim; Sin, Don D; Postma, Dirkje S; Strug, Lisa J; Gallins, Paul J; Paré, Peter D; Bingle, Colin D; Sandford, Andrew J

Saferali, Aabida; Obeidat, Ma'en; Bérubé, Jean-Christophe; Lamontagne, Maxime; Bossé, Yohan; Laviolette, Michel; Hao, Ke; Nickle, David C; Timens, Wim; Sin, Don D; Postma, Dirkje S; Strug, Lisa J; Gallins, Paul J; Paré, Peter D; Bingle, Colin D; Sandford, Andrew J.

Affiliation

Saferali A; 1 Centre for Heart Lung Innovation, UBC and St. Paul's Hospital, Vancouver, British Columbia.
Obeidat M; 1 Centre for Heart Lung Innovation, UBC and St. Paul's Hospital, Vancouver, British Columbia.
Bérubé JC; 2 Institut Universitaire de Cardiologie et de Pneumologie de Québec and.
Lamontagne M; 2 Institut Universitaire de Cardiologie et de Pneumologie de Québec and.
Bossé Y; 2 Institut Universitaire de Cardiologie et de Pneumologie de Québec and.
Laviolette M; 3 Department of Molecular Medicine, Laval University, Québec, Quebec.
Hao K; 2 Institut Universitaire de Cardiologie et de Pneumologie de Québec and.
Nickle DC; 4 Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
Timens W; 5 Merck Research Laboratories, Boston, Massachusetts.
Sin DD; 6 Merck, Rahway, New Jersey.
Postma DS; 7 Genetics, Rosetta Inpharmatics, Merck, Seattle, Washington.
Strug LJ; Departments of 8 Pathology and Medical Biology and.
Gallins PJ; 1 Centre for Heart Lung Innovation, UBC and St. Paul's Hospital, Vancouver, British Columbia.
Paré PD; 9 Pulmonary Medicine and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Bingle CD; 10 Program in Genetics and Genome Biology, The Hospital For Sick Children, and Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Sandford AJ; 11 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and.

Am J Respir Cell Mol Biol ; 53(5): 607-14, 2015 Nov.

Article in En | MEDLINE | ID: mdl-25574903

Subject(s)

Autoantigens/genetics; Cystic Fibrosis/genetics; Glycoproteins/genetics; Lung/metabolism; Phosphoproteins/genetics; Polymorphism, Single Nucleotide; Proteins/genetics; Adolescent; Adult; Alleles; Autoantigens/immunology; Case-Control Studies; Child; Cystic Fibrosis/immunology; Cystic Fibrosis/pathology; Fatty Acid-Binding Proteins; Female; Gene Expression Regulation; Genome-Wide Association Study; Glycoproteins/immunology; Humans; Immunity, Innate; Lung/immunology; Lung/pathology; Male; Phosphoproteins/immunology; Proteins/immunology; Quantitative Trait Loci; RNA, Messenger/genetics; RNA, Messenger/immunology; Saliva/chemistry; Severity of Illness Index; Signal Transduction

Key words

BPIFA1; BPIFB1; PLUNCs; cystic fibrosis; gene modifiers

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Autoantigens / Glycoproteins / Proteins / Polymorphism, Single Nucleotide / Cystic Fibrosis / Lung Type of study: Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Female / Humans / Male Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2015 Type: Article

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