Doxorubicin-loaded glycyrrhetinic acid modified recombinant human serum albumin nanoparticles for targeting liver tumor chemotherapy.

Qi, Wen-Wen; Yu, Hai-Yan; Guo, Hui; Lou, Jun; Wang, Zhi-Ming; Liu, Peng; Sapin-Minet, Anne; Maincent, Philippe; Hong, Xue-Chuan; Hu, Xian-Ming; Xiao, Yu-Ling

Qi, Wen-Wen; Yu, Hai-Yan; Guo, Hui; Lou, Jun; Wang, Zhi-Ming; Liu, Peng; Sapin-Minet, Anne; Maincent, Philippe; Hong, Xue-Chuan; Hu, Xian-Ming; Xiao, Yu-Ling.

Affiliation

Qi WW; State Key Laboratory of Virology, Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, School of Pharmaceutical Sciences, Wuhan University , Wuhan 430071, China.

Mol Pharm ; 12(3): 675-83, 2015 Mar 02.

Article in En | MEDLINE | ID: mdl-25584860

Subject(s)

Antineoplastic Agents/administration & dosage; Doxorubicin/administration & dosage; Liver Neoplasms, Experimental/drug therapy; Nanocapsules/chemistry; Animals; Antineoplastic Agents/pharmacokinetics; Doxorubicin/pharmacokinetics; Drug Delivery Systems; Glycyrrhetinic Acid/chemistry; HeLa Cells; Hep G2 Cells; Humans; Liver Neoplasms, Experimental/metabolism; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanocapsules/administration & dosage; Nanocapsules/ultrastructure; Recombinant Proteins/chemistry; Serum Albumin/chemistry; Tissue Distribution; Xenograft Model Antitumor Assays

Key words

glycyrrhetinic acid; liver cancer targeting; nanoparticle; recombinant human serum albumin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / Nanocapsules / Liver Neoplasms, Experimental / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2015 Type: Article Affiliation country: China

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