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MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition.
Kühn, Michael W M; Hadler, Michael J; Daigle, Scott R; Koche, Richard P; Krivtsov, Andrei V; Olhava, Edward J; Caligiuri, Michael A; Huang, Gang; Bradner, James E; Pollock, Roy M; Armstrong, Scott A.
Affiliation
  • Kühn MW; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Hadler MJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Daigle SR; Epizyme, Inc., Cambridge, MA, USA.
  • Koche RP; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Krivtsov AV; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Olhava EJ; Epizyme, Inc., Cambridge, MA, USA.
  • Caligiuri MA; The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Huang G; Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Bradner JE; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Pollock RM; Epizyme, Inc., Cambridge, MA, USA.
  • Armstrong SA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA armstros@mskcc.org.
Haematologica ; 100(5): e190-3, 2015 May.
Article in En | MEDLINE | ID: mdl-25596271
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia / Gene Duplication / Tandem Repeat Sequences / Myeloid-Lymphoid Leukemia Protein / Methyltransferases / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Haematologica Year: 2015 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia / Gene Duplication / Tandem Repeat Sequences / Myeloid-Lymphoid Leukemia Protein / Methyltransferases / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Haematologica Year: 2015 Type: Article Affiliation country: United States