Sample preparation: a crucial factor for the analytical performance of rationally designed MALDI matrices.
Anal Chem
; 87(3): 1485-8, 2015 Feb 03.
Article
in En
| MEDLINE
| ID: mdl-25597381
ABSTRACT
Evidence is presented that the performance of the rationally designed MALDI matrix 4-chloro-α-cyanocinnamic acid (ClCCA) in comparison to its well-established predecessor α-cyano-4-hydroxycinnamic acid (CHCA) is significantly dependent on the sample preparation, such as the choice of the target plate. In this context, it becomes clear that any rational designs of MALDI matrices and their successful employment have to consider a larger set of physicochemical parameters, including sample crystallization and morphology/topology, in addition to parameters of basic (solution and/or gas-phase) chemistry.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Anal Chem
Year:
2015
Type:
Article
Affiliation country:
United kingdom