Oncoprotein YAP regulates the spindle checkpoint activation in a mitotic phosphorylation-dependent manner through up-regulation of BubR1.

Yang, Shuping; Zhang, Lin; Chen, Xingcheng; Chen, Yuanhong; Dong, Jixin

Yang, Shuping; Zhang, Lin; Chen, Xingcheng; Chen, Yuanhong; Dong, Jixin.

Affiliation

Yang S; From the Department of Oncology, Shandong Provincial Hospital affiliated with Shandong University, Jinan, Shandong 250021, China and the Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198.
Zhang L; the Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198.
Chen X; the Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198.
Chen Y; the Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198.
Dong J; the Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198 dongj@unmc.edu.

J Biol Chem ; 290(10): 6191-202, 2015 Mar 06.

Article in En | MEDLINE | ID: mdl-25605730

Subject(s)

M Phase Cell Cycle Checkpoints/genetics; Nuclear Proteins/biosynthesis; Protein Serine-Threonine Kinases/genetics; Transcription Factors/biosynthesis; Transcription, Genetic; Cell Cycle Proteins; Dual-Specificity Phosphatases/metabolism; Gene Expression Regulation; Humans; MCF-7 Cells; Neoplasms/genetics; Neoplasms/pathology; Nuclear Proteins/genetics; Phosphorylation; Protein Serine-Threonine Kinases/biosynthesis; Protein Serine-Threonine Kinases/metabolism; Transcription Factors/genetics

Key words

BubR1; Hippo Pathway; Mitosis; Oncogene; Phosphorylation; Spindle Checkpoint; Yes-associated Protein (YAP)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Transcription, Genetic / Nuclear Proteins / Protein Serine-Threonine Kinases / M Phase Cell Cycle Checkpoints Limits: Humans Language: En Journal: J Biol Chem Year: 2015 Type: Article

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