Assessment of retinal nerve fiber layer thickness in healthy, full-term neonates.
Am J Ophthalmol
; 159(4): 803-11, 2015 Apr.
Article
in En
| MEDLINE
| ID: mdl-25634528
ABSTRACT
PURPOSE:
To measure average retinal nerve fiber layer (RNFL) thicknesses in healthy, full-term neonates.DESIGN:
Descriptive research to develop normative data.METHODS:
Healthy infants born between 37 and 42 weeks postmenstrual age were imaged with hand-held spectral-domain optical coherence tomography. A custom script segmented the RNFL; the fovea and optic nerve center were manually selected. A second script measured the average RNFL thickness along the papillomacular bundle, defined as the arc from -15 degrees to +15 degrees on the axis from the optic nerve to fovea, with radii of 1.1, 1.3, 1.5, and 1.7 mm from the center of the optic disc. Shapiro-Wilk W tests assessed these measurements for normality to determine the age-appropriate radial distance for subsequent analyses. Average RNFL thicknesses for four temporal 45-degree sectors (superior temporal, temporal superior, temporal inferior, and inferior temporal) and the temporal quadrant were calculated and compared to demographic parameters for all infants.RESULTS:
Fifty full-term infants were adequately imaged for RNFL analysis. RNFL thicknesses at 1.5 mm radial distance from the optic nerve were the most normally distributed. While there was a trend toward greater mean superior temporal RNFL thickness for both black and Hispanic vs white infants (128 ± 27 µm, 124 ± 30 µm, and 100 ± 19 µm, respectively, P = .04 for both comparisons), there were no other significant differences noted in RNFL thicknesses by race, sex, gestational age, or birth weight.CONCLUSIONS:
We present RNFL thickness measurements for healthy, full-term infants that may serve as normative data for future analyses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Optic Disk
/
Retina
/
Retinal Ganglion Cells
/
Term Birth
/
Nerve Fibers
Type of study:
Observational_studies
Limits:
Female
/
Humans
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Male
/
Newborn
Language:
En
Journal:
Am J Ophthalmol
Year:
2015
Type:
Article