Comprehensive metabolomics identifies the alarmin uric acid as a critical signal for the induction of peanut allergy.

Kong, J; Chalcraft, K; Mandur, T S; Jimenez-Saiz, R; Walker, T D; Goncharova, S; Gordon, M E; Naji, L; Flader, K; Larché, M; Chu, D K; Waserman, S; McCarry, B; Jordana, M

Kong, J; Chalcraft, K; Mandur, T S; Jimenez-Saiz, R; Walker, T D; Goncharova, S; Gordon, M E; Naji, L; Flader, K; Larché, M; Chu, D K; Waserman, S; McCarry, B; Jordana, M.

Affiliation

Kong J; Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada.

Allergy ; 70(5): 495-505, 2015 May.

Article in En | MEDLINE | ID: mdl-25647422

Subject(s)

Alarmins/immunology; Peanut Hypersensitivity/immunology; Uric Acid/immunology; Alarmins/metabolism; Animals; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Immunoglobulin E/blood; Immunoglobulin E/immunology; Immunoglobulin G/blood; Immunoglobulin G/immunology; Metabolomics; Mice; Mice, Inbred C57BL; Peanut Hypersensitivity/metabolism; Uric Acid/metabolism

Key words

allergic sensitization; danger-associated molecular pattern; metabolomics; peanut allergy; uric acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uric Acid / Peanut Hypersensitivity / Alarmins Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Allergy Year: 2015 Type: Article Affiliation country: Canada

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