Riparin A, a compound from Aniba riparia, attenuate the inflammatory response by modulation of neutrophil migration.
Chem Biol Interact
; 229: 55-63, 2015 Mar 05.
Article
in En
| MEDLINE
| ID: mdl-25656915
ABSTRACT
Inflammation is a local tissue response to attacks characterized by vascular and cellular events, including intense oxidative stress. Riparin A, a compound obtained from Aniba riparia, has been shown to have antioxidant activity and cytotoxicity in vitro. This study was aimed at evaluating the anti-inflammatory effect of riparin A against acute inflammation. The results of our evaluations in various experimental models indicated that riparin A reduced paw edema induced by carrageenan, compound 48/80, histamine, and serotonin. Furthermore, it decreased leukocyte and neutrophil counts, myeloperoxidase activity, thiobarbituric acid reactive substance (TBARS) levels, and cytokine (tumor necrosis factor-α and interleukin-1ß) levels increased by carrageenan-induced peritonitis, and reversed glutathione levels. Riparin A also reduced carrageenan-induced adhesion and rolling of leukocytes on epithelial cells and did not produce gastric-damage as compared with indomethacin. In conclusion, the data show that riparin A reduces inflammatory response by inhibiting vascular and cellular events, modulating neutrophil migration, inhibiting proinflammatory cytokine production, and reducing oxidative stress.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peritonitis
/
Phenethylamines
/
Benzamides
/
Carrageenan
/
Edema
/
Immune System Diseases
/
Leukocyte Disorders
/
Anti-Inflammatory Agents
/
Neutrophils
Type of study:
Prognostic_studies
Language:
En
Journal:
Chem Biol Interact
Year:
2015
Type:
Article
Affiliation country:
Brazil