Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis.

Ravala, Sandeep K; Singh, Suruchi; Yadav, Ghanshyam S; Kumar, Sanjay; Karthikeyan, Subramanian; Chakraborti, Pradip K

Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis.

Ravala, Sandeep K; Singh, Suruchi; Yadav, Ghanshyam S; Kumar, Sanjay; Karthikeyan, Subramanian; Chakraborti, Pradip K.

Affiliation

Ravala SK; CSIR-Institute of Microbial Technology, Chandigarh, India.

FEBS J ; 282(8): 1419-31, 2015 Apr.

Article in En | MEDLINE | ID: mdl-25665034

Subject(s)

Amino Acid Motifs/genetics; Bacterial Proteins/metabolism; Mycobacterium tuberculosis/enzymology; Protein Serine-Threonine Kinases/metabolism; Serine/metabolism; Threonine/metabolism; Amino Acid Sequence; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Molecular Sequence Data; Mutant Proteins/genetics; Mutant Proteins/metabolism; Mycobacterium tuberculosis/genetics; Phosphorylation; Protein Serine-Threonine Kinases/chemistry; Protein Serine-Threonine Kinases/genetics; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine/chemistry; Serine/genetics; Threonine/chemistry; Threonine/genetics

Key words

activation loop; autophosphorylation; crystal structure; mutagenesis; transphosphorylation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Threonine / Bacterial Proteins / Protein Serine-Threonine Kinases / Amino Acid Motifs / Mycobacterium tuberculosis Type of study: Prognostic_studies Language: En Journal: FEBS J Journal subject: BIOQUIMICA Year: 2015 Type: Article Affiliation country: India

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