Spatially resolved quantification of gadolinium(III)-based magnetic resonance agents in tissue by MALDI imaging mass spectrometry after in vivo MRI.
Angew Chem Int Ed Engl
; 54(14): 4279-83, 2015 Mar 27.
Article
in En
| MEDLINE
| ID: mdl-25689595
ABSTRACT
Gadolinium(III)-based contrast agents improve the sensitivity and specificity of magnetic resonance imaging (MRI), especially when targeted contrast agents are applied. Because of nonlinear correlation between the contrast agent concentration in tissue and the MRI signal obtained inâ
vivo, quantification of certain biological or pathophysiological processes by MRI remains a challenge. Up to now, no technology has been able to provide a spatially resolved quantification of MRI agents directly within the tissue, which would allow a more precise verification of inâ
vivo imaging results. MALDI imaging mass spectrometry for spatially resolved inâ
situ quantification of gadolinium(III) agents, in correlation to inâ
vivo MRI, were evaluated. Enhanced kinetics of Gadofluorineâ
M were determined dynamically over time in a mouse model of myocardial infarction. MALDI imaging was able to corroborate the inâ
vivo imaging MRI signals and enabled in situ quantification of the gadolinium probe with high spatial resolution.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Magnetic Resonance Imaging
/
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/
Contrast Media
/
Gadolinium
Language:
En
Journal:
Angew Chem Int Ed Engl
Year:
2015
Type:
Article