Characterization of nitrazine yellow as a photoacoustically active pH reporter molecule.
Anal Chem
; 87(7): 3623-30, 2015 Apr 07.
Article
in En
| MEDLINE
| ID: mdl-25741857
ABSTRACT
Throughout the fields of biomedical imaging, materials analysis, and routine chemical analysis, it is desirable to have a toolkit of molecules that can allow noninvasive/remote chemical sensing with minimal sample preparation. Here, we describe the photophysical properties involved in photoacoustic (PA) measurements and present a detailed analysis of the requirements and complications involved in PA sensing. We report the use of nitrazine yellow (NY) as a well-behaved PA pH reporter molecule. Both the basic and acidic forms of NY are photoacoustically well-behaved and allow for rapid and noninvasive measurement of pH in either transparent or turbid media. We also find that the serum protein-bound form of NY is photoacoustically well-behaved and should permit applications in noninvasive 3D imaging (e.g., the lymphatic system).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Anal Chem
Year:
2015
Type:
Article
Affiliation country:
United States